Volume-dependent parameters in essential hypertension

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[Total blood volume in essential and secondary hypertension].

To study the role of volume factors in the pathogenesis of hypertension, total blood volume (TBV) was determined in 43 patients with essential hypertension, 10 with primary aldosteronism, 5 with Cushing's syndrome, 5 with renovascular hypertension and 23 age-matched normotensives. The radioisotope (131I) labeled plasma tracer technique was employed under conditions of constant sodium intake (20...

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Relation of plasma to interstitial fluid volume in essential hypertension.

Extracellular water (radiobromine), plasma volume (radioiodinated human serum albumin), and peripheral plasma renin activity were measured simultaneously in men with uncomplicated, untreated essential hypertension and in normal subjects. The ratio of plasma volume to interstitial fluid volume (PV/IF) was significantly lower in hypertensive patients (0.194 vs. 0.223, P < 0.001). This could not b...

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Amlodipine, enalapril, and dependent leg edema in essential hypertension.

Calcium channel blockers (CCBs) blunt postural skin vasoconstriction, an autoregulatory mechanism that minimizes gravitational increases in capillary pressure and avoids fluid extravasation when standing. To evaluate the dose-response relation between this pharmacological interference and dependent edema, a frequent side effect of CCBs during antihypertensive treatment, skin blood flow (laser D...

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Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension.

BACKGROUND Endothelium regulates vascular tone by influencing the contractile activity of vascular smooth muscle. This regulatory effect of the endothelium on blood vessels has been shown to be impaired in atherosclerotic arteries in humans and animals and in animal models of hypertension. METHODS To determine whether patients with essential hypertension have an endothelium-dependent abnormal...

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Abnormal Endothelium-Dependent Vascular Relaxation of Patients With Essential Hypertension

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ژورنال

عنوان ژورنال: Kidney International

سال: 1977

ISSN: 0085-2538

DOI: 10.1038/ki.1977.29